Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18552441 | 1.00 | MAPT (0.49) | MAPTIDO1PDE4APDE4BPDE4C | |
| SCHEMBL16566268 | 0.95 | IDO1 (0.44) | MAPTIDO1PDE4APDE4BPDE4C | |
| SCHEMBL16566110 | 0.91 | IDO1 (0.46) | MAPTIDO1PDE4APDE4BPDE4C | |
| SCHEMBL6307523 | 0.87 | MAPT (0.44) | MAPTIDO1ALDH1A1KDM4EGAA | |
| SCHEMBL23785707 | 0.85 | IDO1 (0.41) | MAPTIDO1ALDH1A1KDM4EGAA | |
| SCHEMBL2982905 | 0.85 | IDO1 (0.41) | MAPTIDO1ALDH1A1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL6249275 | 0.83 | HTR2C (0.41) | MAPTIDO1ALDH1A1KDM4EGAA | |
| SCHEMBL9899738 | 0.81 | IDO1 (0.53) | MAPTIDO1ALDH1A1KDM4EGAA | |
| SCHEMBL23785577 | 0.80 | ALDH1A1 (0.38) | MAPTIDO1ALDH1A1KDM4EGAA | |
| SCHEMBL7467891 | 0.79 | TSHR (0.50) | MAPTALDH1A1KDM4EGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381374-A1 | Phosphodiesterase inhibitors | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-08-08 | — | — | EP | disclosed |