SCHEMBL7375448

SCHEMBL7375448

NC(=O)N1CC[C@](Cc2cccc3nc(N)ccc23)(OC(=O)C(F)(F)F)C1=O

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NCF1 P14598 6/20 0.32
CYBB P04839 2/20 0.32
P2RX7 Q99572 1/20 0.32
ADAM17 P78536 1/20 0.31
NOX5 Q96PH1 1/20 0.31
MGLL Q99685 1/20 0.31
BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7371980 0.82 NOS1 (0.40)
SCHEMBL7379899 0.76 KLKB1 (0.33)
SCHEMBL7382750 0.76
SCHEMBL7379895 0.75 HSP90AB1 (0.35)
SCHEMBL7377308 0.75 HSP90AB1 (0.35)
SCHEMBL7368812 0.75 NR4A2 (0.31)
SCHEMBL7383565 0.73 EIF2AK3 (0.36)
SCHEMBL7374815 0.73 SLC22A12 (0.31)
SCHEMBL7378094 0.73 MAP4K4 (0.34)
SCHEMBL4626498 0.72 PRSS1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086099-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2002-01-02 EP claimed
EP-1086099-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-03-28 EP claimed
WO-1999062904-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-09 WO claimed