Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400877 | 0.92 | PLAU (0.46) | ALDH1A1PLAUTAS2R14MEP1BPTPN1 | |
| SCHEMBL7400241 | 0.91 | PLAU (0.56) | ALDH1A1PLAUPTPN1KDM4E | |
| SCHEMBL7505548 | 0.91 | PLAU (0.47) | ALDH1A1PLAUPTPN1KDM4EMMP3 | |
| SCHEMBL7409426 | 0.87 | PLAU (0.49) | ALDH1A1PLAUTAS2R14PTPN1KDM4E | |
| SCHEMBL7499923 | 0.87 | PLAU (0.47) | ALDH1A1PLAUKDM4ECXCR3 | |
| SCHEMBL6433730 | 0.86 | PLAU (0.47) | ALDH1A1PLAUTAS2R14MEP1BPTGES | |
| SCHEMBL6434320 | 0.86 | TP53 (0.43) | ALDH1A1PLAUTAS2R14KDM4E | |
| SCHEMBL7390607 | 0.84 | PLAU (0.44) | ALDH1A1PLAUTAS2R14KDM4E | |
| SCHEMBL7403796 | 0.83 | PLAU (0.52) | ALDH1A1PLAUKDM4E | |
| SCHEMBL7496370 | 0.81 | PLAU (0.55) | PLAUTAS2R14PTGESMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |