Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.45 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375592 | 0.92 | ALDH1A1 (0.50) | PLAUALDH1A1TAS2R14MEP1BKDM4E | |
| SCHEMBL7409426 | 0.91 | PLAU (0.49) | PLAUALDH1A1TAS2R14DAGLAKDM4E | |
| SCHEMBL7400241 | 0.90 | PLAU (0.56) | PLAUALDH1A1DAGLAMMP9MMP13 | |
| Hydrochloric Acid SCHEMBL7449769 | 0.88 | PLAU (0.44) | PLAUALDH1A1TAS2R14DAGLAMMP9 | |
| SCHEMBL7499923 | 0.87 | PLAU (0.47) | PLAUALDH1A1MMP9MMP13ADAM17 | |
| SCHEMBL6433815 | 0.86 | PLAU (0.47) | PLAUALDH1A1TAS2R14DAGLAMMP9 | |
| SCHEMBL7505548 | 0.86 | PLAU (0.47) | PLAUALDH1A1KDM4EPTPN1 | |
| SCHEMBL6434320 | 0.85 | TP53 (0.43) | PLAUALDH1A1TAS2R14KDM4ELMNA | |
| SCHEMBL7390607 | 0.83 | PLAU (0.44) | PLAUALDH1A1TAS2R14KDM4ELMNA | |
| SCHEMBL7403796 | 0.80 | PLAU (0.52) | PLAUALDH1A1KDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |