Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050066 | 0.92 | PLAU (0.39) | ALDH1A1PLAUMEN1KMT2AMAPT | |
| SCHEMBL7049646 | 0.92 | PLAU (0.43) | NR1D1ALDH1A1PLAUMMP1MMP2 | |
| SCHEMBL7377977 | 0.92 | PLAU (0.36) | NR1D1ALDH1A1KDM4EPLAUMMP1 | |
| SCHEMBL7369748 | 0.91 | PLG (0.44) | ALDH1A1PLAUPLG | |
| SCHEMBL7053013 | 0.90 | PLG (0.43) | ALDH1A1PLAUPLG | |
| SCHEMBL7367643 | 0.90 | ALDH1A1 (0.41) | ALDH1A1MMP1MMP2MMP9MMP8 | |
| SCHEMBL7378343 | 0.90 | PDE4A (0.41) | NR1D1ALDH1A1PDK1PDK2PDK3 | |
| SCHEMBL6436326 | 0.90 | SMN1; SMN2 (0.37) | NR1D1ALDH1A1KDM4EPLAUMMP1 | |
| SCHEMBL7371411 | 0.90 | MAPT (0.39) | NR1D1PLAUMMP1MMP2MMP9 | |
| SCHEMBL7378428 | 0.89 | PDE4A (0.38) | NR1D1ALDH1A1PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |