Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 6/20 | 0.45 |
| ▸ | BCHE | P06276 | 5/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380828 | 0.86 | HTT (0.45) | MAPTALDH1A1HTTKMT2AACHE | |
| SCHEMBL7383945 | 0.81 | ACHE (0.52) | MAPTACHEBCHETP53 | |
| Water SCHEMBL7385383 | 0.81 | ACHE (0.51) | MAPTACHEBCHETP53 | |
| Water SCHEMBL7385385 | 0.81 | ACHE (0.51) | MAPTACHEBCHETP53 | |
| SCHEMBL7388062 | 0.79 | SMYD3 (0.52) | MAPTALDH1A1HTTACHEBCHE | |
| SCHEMBL7382874 | 0.78 | ACHE (0.46) | POLBMAPTALDH1A1HTTKMT2A | |
| SCHEMBL5492773 | 0.74 | ACHE (0.56) | KMT2AACHEBCHECHRM1EPHX2 | |
| SCHEMBL4266767 | 0.72 | ACHE (0.74) | MAPTACHEBCHECHRM1EPHX2 | |
| SCHEMBL7385584 | 0.70 | ACHE (0.51) | POLBRECQLCASP6TDP1L3MBTL1 | |
| SCHEMBL4897542 | 0.69 | SIRT1 (0.67) | MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4851536-A | ANTIFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-07-25 | — | — | US | claimed |
| US-4970316-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-11-13 | — | — | US | disclosed |
| US-4851536-A | ANTIFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |