Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.81 |
| ▸ | HTR2B | P41595 | 8/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.56 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | QPCT | Q16769 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369676 | 0.91 | HTR2C (0.78) | HTR2CHTR2BMAPTGAKRIPK2 | |
| SCHEMBL7454585 | 0.90 | HTR2C (0.77) | HTR2CHTR2BMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7655770 | 0.90 | HTR2C (0.77) | HTR2CHTR2BGAKRIPK2COQ8A | |
| Hydrochloric Acid SCHEMBL7652249 | 0.89 | HTR2C (0.75) | HTR2CHTR2BMEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL7664592 | 0.89 | HTR2C (0.98) | HTR2CHTR2BMEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL7660022 | 0.89 | HTR2C (0.75) | HTR2CHTR2BMAPTGAKRIPK2 | |
| Hydrochloric Acid SCHEMBL7376632 | 0.88 | HTR2C (0.74) | HTR2CHTR2BMAPTGAKRIPK2 | |
| Hydrochloric Acid SCHEMBL7373000 | 0.88 | HTR2C (0.74) | HTR2CHTR2BMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7657753 | 0.86 | HTR2C (0.71) | HTR2CHTR2BKDRIGF1R | |
| SCHEMBL7370903 | 0.84 | HTR2C (0.70) | HTR2CHTR2BMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |