Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29264324 | 0.79 | CCR8 (0.45) | BACE1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL19284731 | 0.75 | CCR8 (0.54) | BACE1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL19284618 | 0.73 | SMN1; SMN2 (0.51) | BACE1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7375251 | 0.72 | PTPN2 (0.61) | PTPN2PTPN1PTPN6MEN1KMT2A | |
| SCHEMBL19297192 | 0.72 | BACE1 (0.46) | BACE1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8143794 | 0.72 | HTR6 (0.46) | BACE1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL6219928 | 0.72 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3KDM4E | |
| SCHEMBL26090256 | 0.72 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3KDM4E | |
| SCHEMBL1088524 | 0.72 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3KDM4E | |
| Trifluoroacetic Acid SCHEMBL7413403 | 0.71 | BACE1 (0.45) | BACE1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6069143-A | Fibrinogen receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0885213-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0885213-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997025323-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |