Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.52 |
| ▸ | GABRE | P78334 | 1/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373538 | 0.91 | GABRA1 (0.51) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7370408 | 0.89 | GABRA1 (0.59) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7373833 | 0.88 | LMNA (0.57) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11829874 | 0.87 | GABRA1 (0.53) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL10470328 | 0.83 | GABRA1 (0.55) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11736760 | 0.81 | GABRA1 (0.54) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11447654 | 0.80 | GABRA1 (0.53) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7374772 | 0.80 | GABRA1 (0.59) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7380036 | 0.78 | LMNA (0.57) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11508138 | 0.78 | GABRA1 (0.51) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801651-B1 | HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| US-6174881-B1 | USED AS ANXIOLYTIC AND/OR ANTICONVULSANT AND/OR MUSCLE RELAXANT AGENTS; SEDATIVES OR HYPNOSIS; WATER-SOLUBLE AMINE SALTS; FAST-ACTING | HOFFMAN-LA ROCHE INC. | 2001-01-16 | — | — | US | disclosed |
| EP-0801651-A1 | HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996020941-A1 | HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-07-11 | — | — | WO | disclosed |