Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 7/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768185 | 0.86 | HPRT1 (0.54) | HPRT1KDM4ETSHRHSD17B10KMT2A | |
| SCHEMBL2913487 | 0.82 | HPRT1 (0.59) | HPRT1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL930873 | 0.79 | HPRT1 (0.47) | HPRT1HSD17B10MEN1KMT2APOLB | |
| Water SCHEMBL6931313 | 0.79 | HPRT1 (0.46) | HPRT1HSD17B10MEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL6935179 | 0.79 | HPRT1 (0.46) | HPRT1HSD17B10MEN1KMT2APOLB | |
| SCHEMBL7684221 | 0.78 | HPRT1 (0.45) | HPRT1KDM4EKMT2ASMN1; SMN2 | |
| Potassium Ion SCHEMBL6932912 | 0.75 | HPRT1 (0.45) | HPRT1MEN1KMT2APOLBMAPT | |
| SCHEMBL5250159 | 0.74 | HPRT1 (0.60) | HPRT1APEX1 | |
| SCHEMBL931907 | 0.73 | MAPT (0.43) | HPRT1KDM4EALOX15HSD17B10MEN1 | |
| SCHEMBL7061691 | 0.73 | HPRT1 (0.59) | HPRT1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303617-B1 | FOR THERAPY OF OBESITY, LOWERING SERUM CHOLESTEROL AND HIGH DENSITY LIPOPROTEIN IN MAMMALS, INHIBITOR OF MONOAMINE OXIDASE | NEOTHERAPEUTICS, INC. | 2001-10-16 | — | — | US | disclosed |
| WO-1999057120-A9 | NOVEL SEROTONIN-LIKE 9-SUBSTITUTED HYPOXANTHINE AND METHODS OF USE | NEOTHERAPEUTICS INC (US) | 2000-02-03 | — | — | WO | disclosed |
| WO-1999057119-A1 | NOVEL DOPAMINE-LIKE 9-SUBSTITUTED HYPOXANTHINE AND METHODS OF USE | NEOTHERAPEUTICS, INC. (US) | 1999-11-11 | — | — | WO | disclosed |
| WO-1999057120-A1 | NOVEL SEROTONIN-LIKE 9-SUBSTITUTED HYPOXANTHINE AND METHODS OF USE | NEOTHERAPEUTICS, INC. (US) | 1999-11-11 | — | — | WO | disclosed |
| WO-1999056550-A1 | METHOD FOR TREATING MIGRAINE IN MAMMALS | NEOTHERAPEUTICS, INC. (US) | 1999-11-11 | — | — | WO | disclosed |