Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 3/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM4B | O94953 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866525 | 0.82 | HPRT1 (0.58) | HPRT1PDE4AADORA2AADORA2BPDE4B | |
| SCHEMBL7375871 | 0.82 | HPRT1 (0.58) | HPRT1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7061691 | 0.80 | HPRT1 (0.59) | HPRT1PNPKDM4AKDM4BKDM5C | |
| SCHEMBL8768185 | 0.78 | HPRT1 (0.54) | HPRT1KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL21383159 | 0.73 | HPRT1 (0.48) | HPRT1KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL3836268 | 0.73 | HPRT1 (0.61) | HPRT1PNP | |
| SCHEMBL930873 | 0.71 | HPRT1 (0.47) | HPRT1KMT2A | |
| SCHEMBL23909407 | 0.70 | HPRT1 (0.45) | HPRT1ADORA2APNPKDM4AKDM4B | |
| SCHEMBL7451801 | 0.70 | HPRT1 (0.45) | HPRT1ADORA2AKDM4AKDM4BKDM5C | |
| Water SCHEMBL6931313 | 0.70 | HPRT1 (0.46) | HPRT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222306-A1 | 2-AMINO PURINE DERIVATIVES AND THEIR USE AS ANTI-HERPETIC AGENTS | Exley, Ray W. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067630-A1 | 2-AMINO PURINE DERIVATIVES AND THEIR USE AS ANTI-HERPETIC AGENTS | EXLEY RAY W (US) | 2009-05-28 | — | — | WO | disclosed |