Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 9/20 | 0.35 |
| ▸ | TMPRSS6 | Q8IU80 | 5/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGAM | P11215 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371385 | 0.81 | SLC7A5 (0.34) | SLC7A5F2TMPRSS6ALOX15SIRT2 | |
| SCHEMBL8624145 | 0.81 | F2 (0.33) | ITGB3ITGA2BSLC7A5F2TMPRSS6 | |
| SCHEMBL6992431 | 0.72 | SLC7A5 (0.35) | ITGB3ITGA2BSLC7A5F2TMPRSS6 | |
| SCHEMBL7376142 | 0.71 | ITGB3 (0.44) | ITGB3ITGA2B | |
| SCHEMBL8175787 | 0.70 | SLC7A5 (0.42) | SLC7A5F2TMPRSS6ALOX15PRSS1 | |
| SCHEMBL8382921 | 0.67 | ITGB3 (0.43) | ITGB3ITGA2BSLC7A5F2TMPRSS6 | |
| SCHEMBL4901667 | 0.64 | SLC7A5 (0.52) | SLC7A5F2TMPRSS6PRSS1 | |
| SCHEMBL4900034 | 0.63 | CA12 (0.54) | ITGB3ITGA2BF2TMPRSS6PRSS1 | |
| SCHEMBL6563518 | 0.63 | ALOX15 (0.40) | SLC7A5F2TMPRSS6ALOX15PRSS1 | |
| SCHEMBL1003573 | 0.62 | SLC7A5 (0.48) | SLC7A5ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730590-B1 | ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | DU PONT PHARM CO (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0970950-A2 | Novel isoxazoline and isoxazole fibrinogen receptor antagonists | DuPont Pharmaceuticals Company (US) | 2000-01-12 | — | — | EP | disclosed |
| US-5849736-A | Isoxazoline and isoxazole fibrinogen receptor antagonists | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| WO-1995014683-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |