SCHEMBL7376244

SCHEMBL7376244

O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1F)=NCC(=S)N2

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 8/20 0.73
GABRA1 P14867 4/20 0.58
GABRA5 P31644 4/20 0.58
GABRA3 P34903 4/20 0.58
GABRA2 P47869 4/20 0.58
GABRB2 P47870 3/20 0.58
GABRG2 P18507 3/20 0.58
GABRB3 P28472 3/20 0.58
GABRP O00591 1/20 0.58
GABRD O14764 1/20 0.58
GABRB1 P18505 1/20 0.58
ADRA1A P35348 1/20 0.58
GABRA4 P48169 1/20 0.58
GABRE P78334 1/20 0.58
GABRA6 Q16445 1/20 0.58
GABRG1 Q8N1C3 1/20 0.58
GABRG3 Q99928 1/20 0.58
GABRQ Q9UN88 1/20 0.58
CCKBR P32239 1/20 0.56
OPRK1 P41145 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10404741 0.91 CHRM1 (0.60) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL7308583 0.87 GABRA1 (0.76) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL7321391 0.86 GABRA1 (0.78) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL7322518 0.85 CHRM1 (1.00) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL7324382 0.82 CHRM1 (0.77) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL11825591 0.81 CHRM1 (0.72) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL11733109 0.80 CHRM1 (0.73) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL30320323 0.80 CHRM1 (1.00) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL7950385 0.80 CHRM1 (1.00) CHRM1GABRA1GABRA5GABRA3GABRA2
SCHEMBL7328311 0.80 CHRM1 (1.00) CHRM1GABRA1GABRA5GABRA3GABRA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801651-B1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS HOFFMANN LA ROCHE (CH) 2001-07-11 EP disclosed
US-6174881-B1 USED AS ANXIOLYTIC AND/OR ANTICONVULSANT AND/OR MUSCLE RELAXANT AGENTS; SEDATIVES OR HYPNOSIS; WATER-SOLUBLE AMINE SALTS; FAST-ACTING HOFFMAN-LA ROCHE INC. 2001-01-16 US disclosed
EP-0801651-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1997-10-22 EP disclosed
WO-1996020941-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1996-07-11 WO disclosed
EP-0041242-B1 CARBAMOYLOXYAMINO-1,4-BENZODIAZEPINES, THEIR PREPARATION AND MEDICINES CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1984-07-11 EP disclosed
US-4395409-A ANXIOLYTIC AGENT HOECHST AKTIENGESELLSCHAFT (DE) 1983-07-26 US disclosed
US-4010177-A [3-Substituted-5-[(di-methylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenones and process THE UPJOHN COMPANY (US) 1977-03-01 US disclosed
US-3933794-A CENTRAL NERVOUS SYSTEM DEPRESSANTS THE UPJOHN COMPANY (US) 1976-01-20 US disclosed