Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 13/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23881527 | 0.87 | CHRM1 (0.77) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL7324382 | 0.87 | CHRM1 (0.77) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL11733109 | 0.85 | CHRM1 (0.73) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL7318175 | 0.85 | GABRA1 (0.73) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7328311 | 0.85 | CHRM1 (1.00) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL7324283 | 0.85 | CHRM1 (0.73) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL30320323 | 0.85 | CHRM1 (1.00) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL10741591 | 0.83 | CHRM1 (0.71) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL11825759 | 0.82 | CHRM1 (0.74) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL8933625 | 0.81 | CHRM1 (0.69) | CHRM1ALOX12SMN1; SMN2GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174881-B1 | USED AS ANXIOLYTIC AND/OR ANTICONVULSANT AND/OR MUSCLE RELAXANT AGENTS; SEDATIVES OR HYPNOSIS; WATER-SOLUBLE AMINE SALTS; FAST-ACTING | HOFFMAN-LA ROCHE INC. | 2001-01-16 | — | — | US | disclosed |
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| US-4959361-A | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists | HOFFMANN-LA ROCHE INC. (US) | 1990-09-25 | — | — | US | disclosed |