Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.71 |
| ▸ | MIF | P14174 | 3/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510039 | 0.83 | MIF (0.51) | PDE5AMIFPDE4BPDE3AMEN1 | |
| SCHEMBL7502606 | 0.83 | ALDH1A1 (0.51) | PDE5AMIFPDE4BPDE3AMEN1 | |
| Ibudilast SCHEMBL30390 | 0.83 | PDE4B (1.00) | PDE5AMIFPDE4BPDE3AMEN1 | |
| Ibudilast SCHEMBL4194864 | 0.83 | PDE4B (1.00) | PDE5AMIFPDE4BPDE3AMEN1 | |
| SCHEMBL5848990 | 0.82 | ALDH1A1 (0.51) | PDE5AMIFPDE4BPDE3AMEN1 | |
| SCHEMBL951965 | 0.82 | MEN1 (0.51) | PDE5AMIFPDE4BPDE3AMEN1 | |
| SCHEMBL31305749 | 0.82 | PDE5A (0.68) | PDE5AMIFPDE4BPDE3AMEN1 | |
| SCHEMBL955510 | 0.81 | MIF (0.50) | PDE5AMIFPDE4BPDE3AMEN1 | |
| SCHEMBL3192852 | 0.81 | PDE5A (0.66) | PDE5AMIFPDE4BPDE3AMEN1 | |
| Ibudilast SCHEMBL1123688 | 0.81 | PDE4B (0.94) | PDE5AMIFPDE4BPDE3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368343-B1 | AMELIORATING COMPOSITION FOR DYSMNESIA | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1993-06-30 | — | — | EP | disclosed |
| US-4990516-A | Pyrazolo (1,5-a)pyridine derivatives | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1991-02-05 | — | — | US | disclosed |
| EP-0368343-A2 | Ameliorating composition for dysmnesia | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1990-05-16 | — | — | EP | disclosed |
| US-4097483-A | HYPOTENSIVE AND ANTISPASMODIC AGENT | KYORIN PHARMACEUTICAL CO., LTD. (JA) | 1978-06-27 | — | — | US | disclosed |
| US-4028370-A | SMOOTH MUSCLE RELAXANTS, CEREBRAL AND CORONARY DILATORS, HYPOTENSIVE AGENTS | KYORIN PHARMACEUTICAL CO., LTD. (JA) | 1977-06-07 | — | — | US | disclosed |