Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352500 | 0.90 | PDE10A (0.51) | PDE10AATMGABRA1GABRG2GABRB3 | |
| SCHEMBL11473387 | 0.87 | SMN1; SMN2 (0.39) | PDE10AATMTGFBR1SMN1; SMN2NPC1 | |
| SCHEMBL9700106 | 0.86 | PDE10A (0.47) | PDE10AATMGABRA1GABRG2GABRB3 | |
| SCHEMBL7369798 | 0.80 | MAPK14 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL9524943 | 0.80 | TGFBR1 (0.46) | PDE10AATMGABRA1GABRG2GABRB3 | |
| SCHEMBL9524516 | 0.80 | PDE10A (0.41) | PDE10AATMGABRA1GABRG2GABRB3 | |
| SCHEMBL9752587 | 0.76 | PDE10A (0.60) | PDE10ATGFBR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7376928 | 0.75 | PDE10A (0.46) | PDE10AATMGABRA1GABRG2GABRB3 | |
| SCHEMBL9199906 | 0.74 | PDE10A (0.57) | PDE10AATMTGFBR1SMN1; SMN2NPC1 | |
| SCHEMBL7343693 | 0.74 | TGFBR1 (0.65) | PDE10ATGFBR1SMN1; SMN2MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411754-A2 | Medicament for the inhibition of interleukin-1 or tumor necrosis factor production by monocytes and/or macrophages | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-06 | — | — | EP | claimed |
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | claimed |
| EP-0403251-A2 | Monokine activity interference | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | claimed |
| US-5317019-A | Antiinflammatory agents | SMITHKLINE BEECHAM CORP. (US) | 1994-05-31 | — | — | US | disclosed |
| US-5145858-A | Antiinflammatory | SMITHKLINE BEECHAM CORP. (US) | 1992-09-08 | — | — | US | disclosed |
| EP-0411754-A2 | Medicament for the inhibition of interleukin-1 or tumor necrosis factor production by monocytes and/or macrophages | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-06 | — | — | EP | disclosed |
| WO-1991000092-A1 | INHIBITION OF INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR PRODUCTION BY MONOCYTES AND/OR MACROPHAGES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-10 | — | — | WO | disclosed |
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |
| EP-0403251-A2 | Monokine activity interference | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0364204-A1 | Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-18 | — | — | EP | disclosed |
| EP-0306300-A2 | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-03-08 | — | — | EP | disclosed |