Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352500 | 0.87 | PDE10A (0.51) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9524943 | 0.84 | TGFBR1 (0.46) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL11473387 | 0.84 | SMN1; SMN2 (0.39) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9700106 | 0.83 | PDE10A (0.47) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9275639 | 0.82 | GRM2 (0.35) | PDE10ASLC6A7GABRA1GABRG2GABRB3 | |
| SCHEMBL13430532 | 0.80 | TGFBR1 (0.58) | PDE10ATGFBR1ATMTGFBR2PDE4D | |
| SCHEMBL7377237 | 0.80 | PDE10A (0.51) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL7370178 | 0.79 | TGFBR1 (0.38) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9524502 | 0.78 | PDE10A (0.50) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL27309763 | 0.78 | ATM (0.61) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561898-A1 | NOVEL PROCESS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-29 | — | — | EP | claimed |
| WO-1992010499-A1 | NOVEL PROCESS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-06-25 | — | — | WO | claimed |