Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2615998 | 0.79 | GRM4 (0.40) | GRM4KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL17826978 | 0.76 | GRM4 (0.38) | GRM4KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL31165729 | 0.76 | GRM4 (0.41) | GRM4KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL7377529 | 0.76 | KDM4E (0.53) | KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL855507 | 0.76 | GRM4 (0.41) | GRM4KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL24756927 | 0.76 | GRM4 (0.38) | GRM4KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL10164894 | 0.76 | EPAS1 (0.38) | GRM4ALDH1A1 | |
| SCHEMBL7372919 | 0.76 | CHRM4 (0.31) | — | |
| SCHEMBL7375019 | 0.76 | GRM4 (0.34) | GRM4 | |
| SCHEMBL7378229 | 0.76 | EPAS1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | claimed |
| US-5763469-A | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | disclosed |