Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 9/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377972 | 0.76 | GRM4 (0.38) | — | |
| SCHEMBL11443229 | 0.73 | EPAS1 (0.61) | EPAS1 | |
| SCHEMBL7377529 | 0.72 | KDM4E (0.53) | — | |
| SCHEMBL7375019 | 0.71 | GRM4 (0.34) | — | |
| SCHEMBL7372919 | 0.71 | CHRM4 (0.31) | — | |
| SCHEMBL7375260 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL7220170 | 0.68 | EPHX2 (0.40) | STK17B | |
| SCHEMBL7214758 | 0.68 | GSK3B (0.44) | — | |
| SCHEMBL18879061 | 0.58 | CYP2A6 (0.36) | — | |
| SCHEMBL18936083 | 0.57 | HDAC3 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | claimed |
| US-5763469-A | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | disclosed |