Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377130 | 0.86 | PRKAG1 (0.47) | KDM4EMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL6993979 | 0.82 | KDM4C (0.65) | KDM4CKDM4EPKMMAPTLMNA | |
| SCHEMBL7373954 | 0.80 | KMT2A (0.43) | KDM4EMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL6993983 | 0.76 | KDM4C (0.56) | KDM4CKDM4ELMNASMN1; SMN2CYP1A2 | |
| SCHEMBL8075999 | 0.74 | SMN1; SMN2 (0.49) | KDM4EMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1009945 | 0.70 | KDM4C (0.52) | KDM4CKDM4EPKMMAPTLMNA | |
| SCHEMBL28954025 | 0.70 | KDM4C (0.53) | KDM4CKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL4794844 | 0.70 | KDM4E (0.63) | KDM4EMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5028345 | 0.70 | LMNA (0.46) | MAPTLMNASMN1; SMN2NPC1ALPL | |
| SCHEMBL7441041 | 0.69 | LMNA (0.57) | KDM4CKDM4EPKMMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140941-A1 | NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039131-A1 | NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |