Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378193 | 1.00 | LMNA (0.53) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7378192 | 1.00 | LMNA (0.53) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7422455 | 0.86 | CA1 (0.43) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15184112 | 0.78 | ALDH1A1 (0.41) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL21461267 | 0.78 | ALDH1A1 (0.32) | ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL8149048 | 0.78 | ALDH1A1 (0.41) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1101922 | 0.77 | ALDH1A1 (0.70) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7382903 | 0.77 | ALDH1A1 (0.70) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7382899 | 0.77 | ALDH1A1 (0.70) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7715767 | 0.74 | CNR2 (0.41) | ALDH1A1KMT2AMEN1SMN1; SMN2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409929-A | Treating psychosis, dyskinesia | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-25 | — | — | US | disclosed |
| WO-1993016047-A1 | HYDROISOINDOLINES AND HYDROISOQUINOLINES AS PSYCHOTROPIC DRUGS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-08-19 | — | — | WO | disclosed |
| US-5216018-A | Antidyskinetic agents | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-06-01 | — | — | US | disclosed |