Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.34 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669909 | 0.85 | CFTR (0.42) | ALDH1A1KDM4EHSD17B3NOTUMMAPK1 | |
| SCHEMBL7377409 | 0.72 | HDAC8 (0.39) | ALDH1A1HPGDHSD17B10KDM4EPIM1 | |
| SCHEMBL7377413 | 0.72 | HDAC8 (0.39) | ALDH1A1HPGDHSD17B10KDM4EPIM1 | |
| SCHEMBL7377416 | 0.72 | HDAC8 (0.39) | ALDH1A1HPGDHSD17B10KDM4EPIM1 | |
| SCHEMBL7555698 | 0.67 | HDAC8 (0.46) | ALDH1A1KDM4ENOTUMMAPK1MAP2K4 | |
| SCHEMBL27813563 | 0.66 | GAA (0.55) | ALDH1A1HPGDHSD17B10KDM4EPIM1 | |
| SCHEMBL7382707 | 0.66 | HDAC8 (0.38) | ALDH1A1KDM4EPIM1PIM2NOTUM | |
| SCHEMBL7382702 | 0.66 | HDAC8 (0.38) | ALDH1A1KDM4EPIM1PIM2NOTUM | |
| SCHEMBL7382705 | 0.66 | HDAC8 (0.38) | ALDH1A1KDM4EPIM1PIM2NOTUM | |
| SCHEMBL6752918 | 0.65 | CFTR (0.46) | ALDH1A1HPGDHSD17B10NOTUMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000067-B1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-10-23 | — | — | EP | disclosed |
| EP-1000067-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | Aventis Pharma S.A. (FR) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005147-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1999-02-04 | — | — | WO | disclosed |