Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377413 | 1.00 | HDAC8 (0.39) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7377416 | 1.00 | HDAC8 (0.39) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7382705 | 0.88 | HDAC8 (0.38) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7382707 | 0.88 | HDAC8 (0.38) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7382702 | 0.88 | HDAC8 (0.38) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7385459 | 0.78 | HTR2A (0.40) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7385453 | 0.78 | HTR2A (0.40) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7385461 | 0.78 | HTR2A (0.40) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7555698 | 0.77 | HDAC8 (0.46) | HDAC8GAAMAPK1MEN1MAPT | |
| SCHEMBL7378403 | 0.72 | ALDH1A1 (0.37) | MAPK1MEN1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000067-B1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-10-23 | — | — | EP | disclosed |
| US-6369221-B1 | Thiazolobenzoheterocycles, preparation and medicines containing same | AVENTIS PHARMA S.A. (FR) | 2002-04-09 | — | — | US | disclosed |
| EP-1000067-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | Aventis Pharma S.A. (FR) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005147-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1999-02-04 | — | — | WO | disclosed |