Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.39 |
| ▸ | PNMT | P11086 | 4/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31509381 | 0.87 | HDAC8 (0.45) | HDAC8KMT2AMEN1GAAMAPT | |
| SCHEMBL652636 | 0.81 | HDAC8 (0.41) | HDAC8KMT2AMEN1GAAALDH1A1 | |
| SCHEMBL8088198 | 0.79 | DRD2 (0.46) | HDAC8MAPTKDM4E | |
| SCHEMBL1016128 | 0.79 | PNMT (0.47) | ALDH1A1NOTUMPNMTAADATKDM4E | |
| SCHEMBL7377409 | 0.77 | HDAC8 (0.39) | HDAC8KMT2AMEN1GAAMAPT | |
| SCHEMBL7377413 | 0.77 | HDAC8 (0.39) | HDAC8KMT2AMEN1GAAMAPT | |
| SCHEMBL7377416 | 0.77 | HDAC8 (0.39) | HDAC8KMT2AMEN1GAAMAPT | |
| SCHEMBL27813563 | 0.77 | GAA (0.55) | HDAC8KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL6754972 | 0.75 | HDAC8 (0.41) | HDAC8KMT2AMEN1GAAMAPT | |
| SCHEMBL6754969 | 0.75 | HDAC8 (0.41) | HDAC8KMT2AMEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966473-B1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-07-24 | — | — | EP | disclosed |
| EP-0966473-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | Aventis Pharma S.A. (FR) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998038194-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1998-09-03 | — | — | WO | disclosed |