Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381132 | 0.86 | TGFBR1 (0.67) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9701135 | 0.84 | PDE10A (0.55) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL7352490 | 0.84 | PDE10A (0.60) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL7377231 | 0.84 | PDE10A (0.60) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9701112 | 0.83 | PDE10A (0.57) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9436323 | 0.83 | TGFBR1 (0.63) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9700069 | 0.81 | PDE10A (0.55) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9700092 | 0.81 | PDE10A (0.56) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL7378515 | 0.80 | TGFBR1 (0.65) | PDE10ATGFBR1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL7343693 | 0.80 | TGFBR1 (0.65) | PDE10ATGFBR1SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533837-A4 | INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 1994-11-17 | — | — | EP | disclosed |
| EP-0533837-A1 | INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991019497-A1 | INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |
| EP-0411754-A2 | Medicament for the inhibition of interleukin-1 or tumor necrosis factor production by monocytes and/or macrophages | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-06 | — | — | EP | disclosed |
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |
| EP-0403251-A2 | Monokine activity interference | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |