Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.52 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.51 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027940 | 0.93 | NR5A1 (0.59) | SMN1; SMN2CYP2D6KDM4ECYP1A2PDE4A | |
| SCHEMBL27774512 | 0.93 | KDM4E (0.62) | SMN1; SMN2CYP2D6KDM4ECYP1A2PDE4A | |
| SCHEMBL8860730 | 0.91 | NR5A1 (0.62) | SMN1; SMN2CYP2D6KDM4ECYP1A2PDE4A | |
| SCHEMBL22589086 | 0.79 | MEN1 (0.63) | SMN1; SMN2PLA2G4BNR5A1ALDH1A1LMNA | |
| SCHEMBL13106423 | 0.79 | LMNA (0.55) | SMN1; SMN2NR5A1ALDH1A1LMNAMEN1 | |
| SCHEMBL2669633 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2CYP2D6KDM4ECYP1A2PDE4A | |
| SCHEMBL8347541 | 0.79 | KDM4E (0.68) | SMN1; SMN2CYP2D6KDM4ECYP1A2PDE4A | |
| SCHEMBL6650453 | 0.77 | NQO1 (0.61) | SMN1; SMN2KDM4ECYP1A2ALDH1A1LMNA | |
| SCHEMBL10629620 | 0.77 | RARB (0.64) | SMN1; SMN2CYP2D6KDM4ENR5A1ALDH1A1 | |
| SCHEMBL8862587 | 0.77 | FFAR1 (0.63) | PLA2G4BLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5198448-A | Cardiovascular disorders | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |