Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.33 |
| ▸ | CBFB | Q13951 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381518 | 0.84 | ALDH1A1 (0.33) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL4996647 | 0.73 | MKNK1 (0.50) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL7382008 | 0.73 | ALDH1A1 (0.36) | FFAR2ALDH1A1GAAMAPTHPGD | |
| SCHEMBL7414883 | 0.73 | ALDH1A1 (0.36) | FFAR2ALDH1A1GAAMAPTHPGD | |
| SCHEMBL7378061 | 0.72 | ALDH1A1 (0.34) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL7381515 | 0.70 | ALDH1A1 (0.33) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL7379089 | 0.70 | FDPS (0.40) | CYP2C19 | |
| SCHEMBL9133011 | 0.68 | CSNK2A1 (0.51) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL1145924 | 0.68 | HRH3 (0.50) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL9133922 | 0.67 | MAPT (0.60) | ALDH1A1GAAMAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |