Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | PREP | P48147 | 2/20 | 0.48 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10832646 | 0.92 | PREP (0.47) | CASP1PREPGAALMNASMN1; SMN2 | |
| SCHEMBL876242 | 0.83 | CASP1 (0.48) | CASP1GAALMNASMN1; SMN2CA12 | |
| SCHEMBL10513169 | 0.81 | GAA (0.54) | PREPGAALMNASMN1; SMN2CA12 | |
| SCHEMBL15201849 | 0.80 | F10 (0.56) | PREPGAALMNASMN1; SMN2CA12 | |
| SCHEMBL10493479 | 0.78 | PREP (0.47) | PREPGAALMNASMN1; SMN2CA12 | |
| SCHEMBL5647759 | 0.77 | LIPE (0.49) | GAALMNASMN1; SMN2CA12CA1 | |
| SCHEMBL7045087 | 0.77 | NPC1 (0.61) | PREPGAALMNASMN1; SMN2CA12 | |
| SCHEMBL10671107 | 0.77 | GAA (0.46) | PREPGAALMNASMN1; SMN2CA12 | |
| SCHEMBL3864756 | 0.77 | HTT (0.53) | PREPGAALMNASMN1; SMN2CA12 | |
| SCHEMBL2553604 | 0.77 | HTT (0.53) | PREPGAALMNASMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975612-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-06-13 | — | — | EP | claimed |
| EP-0975612-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-02 | — | — | EP | claimed |
| WO-1998046582-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-22 | — | — | WO | claimed |
| EP-0975612-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-0975612-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046582-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-22 | — | — | WO | disclosed |