Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381768 | 1.00 | HCRTR1 (0.57) | HCRTR1HCRTR2HSD11B1MTNR1B | |
| SCHEMBL7379923 | 1.00 | HCRTR1 (0.57) | HCRTR1HCRTR2HSD11B1MTNR1B | |
| SCHEMBL23459119 | 0.84 | HSD11B1 (0.55) | HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL14417553 | 0.84 | HSD11B1 (0.55) | HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL9743616 | 0.83 | HCRTR1 (0.59) | HCRTR1HCRTR2 | |
| SCHEMBL9743610 | 0.83 | HCRTR1 (0.59) | HCRTR1HCRTR2 | |
| SCHEMBL23459022 | 0.83 | ABHD6 (0.54) | HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL23477764 | 0.80 | ABHD6 (0.54) | HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL23477958 | 0.79 | ESR1 (0.41) | HSD11B1 | |
| SCHEMBL14417563 | 0.79 | UTS2R (0.43) | HCRTR1HCRTR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135944-A | Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure | SYNTEX (U.S.A.) INC. (US) | 1992-08-04 | — | — | US | disclosed |
| US-5100912-A | Hypotensive agents, treatment of congestive heart failure | SYNTEX (U.S.A.) INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0426075-A1 | Benzylpyrrolidine derivatives as dopamine agonists | SYNTEX (U.S.A.) INC. (US) | 1991-05-08 | — | — | EP | disclosed |
| EP-0404115-A1 | Bis(benzylpyrrolidine)Derivatives as dopamine agonists | SYNTEX (U.S.A.) INC. (US) | 1990-12-27 | — | — | EP | disclosed |