Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048121 | 0.83 | MAPT (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL6741206 | 0.83 | MAPT (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL27979641 | 0.83 | MAPT (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL16022549 | 0.82 | MAPT (0.64) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL19290957 | 0.82 | MAPT (0.64) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL10651920 | 0.82 | MAPT (0.64) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL6742277 | 0.81 | MAPT (0.66) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL6742274 | 0.81 | MAPT (0.66) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL24106805 | 0.81 | MAPT (0.54) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL28531602 | 0.81 | MAPT (0.54) | SIGMAR1MAPTPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166341-A | Selective antagonist of serotonin 3(5-HT3) receptor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5017573-A | Serotonin receptor antagonist | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0358903-A2 | Indazole-3-carboxylic acid derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |