Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PARL | Q9H300 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7387576 | 0.94 | AKR1C1 (0.49) | HSD11B1MGLLOPRM1OPRD1OPRK1 | |
| SCHEMBL7385618 | 0.94 | AKR1C1 (0.53) | AKR1C1CHRM3MEN1KMT2AMAPK1 | |
| SCHEMBL20591531 | 0.83 | MEN1 (0.38) | HSD11B1MGLLSLC6A4MEN1KMT2A | |
| SCHEMBL21848402 | 0.83 | HSD11B1 (0.44) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL24097137 | 0.77 | AKR1C1 (0.47) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL28653670 | 0.77 | AKR1C1 (0.51) | AKR1C1CHRM3MEN1KMT2AMAPK1 | |
| SCHEMBL23969611 | 0.76 | AKR1C1 (0.50) | HSD11B1AKR1C1CHRM3MEN1KMT2A | |
| SCHEMBL30731583 | 0.76 | AKR1C1 (0.50) | HSD11B1AKR1C1CHRM3MEN1KMT2A | |
| SCHEMBL382726 | 0.73 | AKR1C1 (0.53) | HSD11B1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL23969626 | 0.72 | HSD11B1 (0.45) | HSD11B1OPRM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281617-A | Enzyme inhibitor | CORTECH, INC. (US) | 1994-01-25 | — | — | US | claimed |
| US-5281617-A | Enzyme inhibitor | CORTECH, INC. (US) | 1994-01-25 | — | — | US | disclosed |