Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 10/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381807 | 0.93 | SLC6A4 (0.50) | CACNA1SHRH1SLC6A4LMNAMAPT | |
| SCHEMBL10350239 | 0.87 | CACNA1S (0.51) | CACNA1SHRH1SLC6A4LMNAMAPT | |
| SCHEMBL10350435 | 0.87 | SIGMAR1 (0.43) | CACNA1SHRH1SLC6A4ALDH1A1SMPD1 | |
| SCHEMBL10350422 | 0.84 | HTR7 (0.38) | CACNA1SDRD2HTR7CHRM2ADRA1A | |
| SCHEMBL10350978 | 0.82 | CACNA1S (0.37) | CACNA1SLMNADRD2HTR7SLC6A2 | |
| SCHEMBL10692391 | 0.76 | CACNA1S (0.57) | CACNA1SHRH1SLC6A4LMNAMAPT | |
| SCHEMBL16547305 | 0.75 | SLC6A4 (0.51) | CACNA1SHRH1SLC6A4LMNAMAPT | |
| SCHEMBL16536186 | 0.75 | SLC6A4 (0.51) | CACNA1SHRH1SLC6A4LMNAMAPT | |
| Hydrochloric Acid SCHEMBL16535503 | 0.74 | CACNA1S (0.50) | CACNA1SHRH1SLC6A4LMNAMAPT | |
| SCHEMBL10350980 | 0.73 | MAPT (0.32) | MAPTALDH1A1SCN9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369334-A2 | 1-Aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodiazepine-2-ones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-05-23 | — | — | EP | claimed |
| US-4908360-A | Hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | claimed |
| JP-2188572-A | — | — | None | — | — | JP | disclosed |
| JP-H02188572-A | 1-AMINOALKYL-3-OXYSUBSTITUTED-4-ARYL-1,3,4,5-TETRAHYDRO-2 H-1,3-BENZODIAZEPIN-2-ONE | HOECHST ROUSSEL PHARMACEUT INC | 1990-07-24 | — | — | JP | disclosed |
| EP-0369334-A2 | 1-Aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodiazepine-2-ones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-05-23 | — | — | EP | disclosed |