Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.89 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.89 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.89 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.89 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.89 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.89 |
| ▸ | CCKBR | P32239 | 1/20 | 0.89 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.89 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.89 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300791 | 0.95 | ADORA3 (0.81) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| SCHEMBL7300796 | 0.95 | ADORA3 (0.81) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| Nilvadipine SCHEMBL11913265 | 0.94 | ADORA3 (1.00) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| Nilvadipine SCHEMBL8004036 | 0.94 | ADORA3 (1.00) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| Nilvadipine SCHEMBL33729 | 0.94 | ADORA3 (1.00) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| Nilvadipine SCHEMBL30875962 | 0.94 | ADORA3 (1.00) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| Nilvadipine SCHEMBL33730 | 0.94 | ADORA3 (1.00) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| Nilvadipine SCHEMBL6044973 | 0.94 | ADORA3 (1.00) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| SCHEMBL7378579 | 0.90 | CACNA1F (0.80) | ADORA3ABCB1TBXA2RSCN5ANR1I2 | |
| SCHEMBL30648615 | 0.89 | HIF1A (0.87) | ADORA3ABCB1TBXA2RSCN5ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | claimed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |