Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nilvadipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F known ✓ | O60840 | 2/20 | 0.60 |
| ▸ | CACNA1D known ✓ | Q01668 | 2/20 | 0.60 |
| ▸ | CACNA1S known ✓ | Q13698 | 2/20 | 0.60 |
| ▸ | CACNA1C known ✓ | Q13936 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | CCKBR | P32239 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 1/20 | 1.00 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nilvadipine SCHEMBL11913265 | 1.00 | ADORA3 (1.00) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Nilvadipine SCHEMBL30875962 | 1.00 | ADORA3 (1.00) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Nilvadipine SCHEMBL6044973 | 1.00 | ADORA3 (1.00) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Nilvadipine SCHEMBL33730 | 1.00 | ADORA3 (1.00) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Nilvadipine SCHEMBL33729 | 1.00 | ADORA3 (1.00) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| SCHEMBL7380227 | 0.94 | ADORA3 (0.89) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Nilvadipine SCHEMBL8170123 | 0.94 | ADORA3 (0.88) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Nilvadipine SCHEMBL1538947 | 0.93 | ADORA3 (0.87) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Nilvadipine SCHEMBL7625807 | 0.93 | ADORA3 (0.85) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| SCHEMBL30357961 | 0.90 | ADORA3 (0.81) | ADORA3NR1I2NR3C1ABCB1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150470-A | NEUTRALIZED ETHYLENE-(METH)ACRYLIC ACID POLYMER | SPALDING SPORTS WORLDWIDE, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6100336-A | COMPRISING BLENDS OF HIGH OR LOW ACID COPOLYMERS WITH ETHYLENE ALKYL ACRYLATES; CARBOXYLIC ACID GROUPS OF THE BLENDS ARE NEUTRALIZED WITH METAL CATIONS; BALLS EXHIBIT DESIRED PROPERTIES OF DISTANCE AND COEFFICIENT OF RESTITUTION | SPALDING SPORTS WORLDWIDE, INC. (US) | 2000-08-08 | — | — | US | disclosed |
| US-5591803-A | BLEND OF NEUTRALIZED ACRYLIC ACID-ETHYLENE COPOLYMER AND ALKYL ACRYLATE-ETHYLENE COPOLYMER; PLAYABILITY, DURABILITY | LISCO, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5542677-A | BLENDS COMPRISING A HIGH ACID IONOMER COPOLYMER NEUTRALIZED WITH A METAL CATION; RESILIENCE, HARDNESS, NONCRACKING | LISCO, INC. (US) | 1996-08-06 | — | — | US | disclosed |