Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372592 | 0.86 | ITGB3 (0.39) | ITGB3ITGA2BSMN1; SMN2PARP1PARP10 | |
| SCHEMBL7348070 | 0.79 | HTT (0.38) | ITGB3ITGA2BSMN1; SMN2PARP1PARP10 | |
| SCHEMBL7340322 | 0.77 | EPHX2 (0.37) | ITGB3ITGA2BSMN1; SMN2PARP1PARP10 | |
| SCHEMBL7343615 | 0.70 | SMN1; SMN2 (0.38) | ITGB3ITGA2BSMN1; SMN2PARP1PARP10 | |
| SCHEMBL7379949 | 0.69 | ITGB3 (0.51) | ITGB3ITGA2BSMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL7380345 | 0.68 | KCNK3 (0.50) | ITGB3ITGA2BSMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL8441143 | 0.68 | PARP1 (0.40) | ITGB3ITGA2BPARP1PARP10ROCK2 | |
| SCHEMBL7340450 | 0.68 | HTT (0.37) | ITGB3ITGA2BSMN1; SMN2EPHX2MEN1 | |
| SCHEMBL8500073 | 0.68 | MAPT (0.49) | ITGB3ITGA2BSMN1; SMN2ITGAVKMT2A | |
| SCHEMBL7347196 | 0.67 | HTT (0.37) | ITGB3ITGA2BSMN1; SMN2PARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |