Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.75 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944846 | 0.86 | HSP90AB1 (1.00) | HSP90AA1HSP90AB1LMNAKDM4ERAB9A | |
| SCHEMBL7375654 | 0.80 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1LMNAKDM4EMAPT | |
| SCHEMBL15757500 | 0.79 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1LMNAPTPN1AGPAT2 | |
| SCHEMBL7383642 | 0.79 | SCN2A (0.49) | HSP90AA1HSP90AB1AGPAT2HTR2BPDE4D | |
| SCHEMBL1759878 | 0.77 | MAPT (0.72) | HSP90AA1HSP90AB1LMNAKDM4ERAB9A | |
| SCHEMBL3602925 | 0.77 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1LMNAKDM4ERAB9A | |
| SCHEMBL7379292 | 0.76 | KDM4E (0.62) | HSP90AA1HSP90AB1KDM4ERAB9ANPC1 | |
| SCHEMBL9566485 | 0.76 | HTR2B (0.72) | HSP90AA1HSP90AB1LMNAKDM4ERAB9A | |
| SCHEMBL6049475 | 0.74 | HSP90AB1 (0.59) | HSP90AA1HSP90AB1LMNAKDM4ERAB9A | |
| SCHEMBL7382138 | 0.74 | NUDT1 (0.66) | HSP90AA1HSP90AB1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459830-A1 | Pharmacologically active CNS compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | claimed |
| EP-0459830-A1 | Pharmacologically active CNS compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |