Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | P2RY12 | Q9H244 | 9/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943546 | 0.84 | PDE3B (0.70) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL8943438 | 0.81 | PDE3B (0.60) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL8943402 | 0.80 | PDE3B (0.70) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL9693701 | 0.80 | PDE3B (1.00) | PDE3BPDE3ATSHR | |
| SCHEMBL10760809 | 0.78 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL10758046 | 0.75 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL1493250 | 0.72 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL9364577 | 0.71 | CYP1A2 (0.96) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL32659884 | 0.71 | PDE3B (0.66) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL10758549 | 0.70 | PDE3B (1.00) | PDE3BPDE3AP2RY12PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521187-A | PHOSPHODIESTERASE INHIBITORS, ANTIALLERGENS AND ATOPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-28 | — | — | US | disclosed |
| US-5516908-A | ANTIALLERGENS, ATROPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-14 | — | — | US | disclosed |
| EP-0610372-B1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 1995-12-13 | — | — | EP | disclosed |
| EP-0610372-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS. | JANSSEN PHARMACEUTICA NV (BE) | 1994-08-17 | — | — | EP | disclosed |
| WO-1993009118-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-13 | — | — | WO | disclosed |
| EP-0541153-A1 | 1,3-Dihydro-2H-imidazo[4,5-b]-quinolin-2-one derivatives as phosphodiesterase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-12 | — | — | EP | disclosed |