Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 13/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693445 | 0.83 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL7380497 | 0.80 | PDE3B (0.66) | PDE3BPDE3ATSHR | |
| SCHEMBL9691872 | 0.80 | PDE3B (0.78) | PDE3BPDE3A | |
| SCHEMBL7034123 | 0.80 | PDE3B (0.66) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL9692011 | 0.79 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL8500022 | 0.79 | PDE3B (0.65) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL9691758 | 0.75 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL9693383 | 0.75 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL9692111 | 0.74 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL9693319 | 0.74 | PDE3B (1.00) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | claimed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | claimed |
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |