Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9572745 | 0.82 | ALDH1A1 (0.57) | POLBACHEMEN1KMT2AHSD17B10 | |
| SCHEMBL4772258 | 0.81 | SIGMAR1 (0.61) | SIGMAR1MC4RLMNAPOLBHRH3 | |
| SCHEMBL8380136 | 0.78 | SIGMAR1 (0.57) | SIGMAR1MC4RLMNAPOLBHRH3 | |
| SCHEMBL5036890 | 0.77 | KMT2A (0.48) | SIGMAR1LMNAACHEMEN1KMT2A | |
| SCHEMBL3168599 | 0.76 | SIGMAR1 (0.66) | SIGMAR1LMNAACHEMEN1KMT2A | |
| SCHEMBL2257602 | 0.76 | SIGMAR1 (0.59) | SIGMAR1MC4RLMNAPOLBHRH3 | |
| SCHEMBL4506489 | 0.75 | SIGMAR1 (0.53) | SIGMAR1MC4RLMNAPOLBHRH3 | |
| SCHEMBL2452523 | 0.75 | SIGMAR1 (0.57) | SIGMAR1MC4RLMNAPOLBHRH3 | |
| SCHEMBL28543867 | 0.75 | SIGMAR1 (0.57) | SIGMAR1MC4RLMNAPOLBHRH3 | |
| SCHEMBL15012035 | 0.74 | SIGMAR1 (0.68) | SIGMAR1MC4RLMNAPOLBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562832-A1 | Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1993-09-29 | — | — | EP | disclosed |
| US-5116846-A | N-ARALKYL PIPERIDINE DERIVATIVES AS PSYCHOTROPIC DRUGS | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0449186-A2 | N-aralkyl piperidine derivatives as psychotropic drugs | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |