Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 8/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386327 | 0.95 | POLB (0.45) | POLBRENCYP2D6CYP2C19CYP3A4 | |
| SCHEMBL7416551 | 0.89 | CYP3A4 (0.44) | POLBCYP2D6CYP2C19CYP3A4MMP8 | |
| SCHEMBL7382521 | 0.89 | CYP3A4 (0.43) | POLBCYP2D6CYP2C19CYP3A4MMP8 | |
| SCHEMBL7384151 | 0.87 | CYP3A4 (0.46) | POLBCYP2D6CYP2C19CYP3A4MMP8 | |
| SCHEMBL7292418 | 0.87 | ACE (0.52) | RENMMP8 | |
| SCHEMBL7292424 | 0.87 | ACE (0.52) | RENMMP8 | |
| SCHEMBL7291349 | 0.84 | ACE (0.51) | — | |
| SCHEMBL7291337 | 0.84 | ACE (0.51) | — | |
| SCHEMBL7383775 | 0.83 | CYP3A4 (0.44) | POLBCYP2D6CYP2C19CYP3A4MMP8 | |
| SCHEMBL7375688 | 0.82 | HRH4 (0.46) | POLBCYP2D6CYP2C19CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853476-A | Phosphorus containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1989-08-01 | — | — | US | disclosed |