Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035724 | 0.86 | KDM4E (0.68) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL29676073 | 0.86 | KDM4E (0.68) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL8222573 | 0.83 | CYP2C9 (0.59) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL9008583 | 0.81 | CACNA1B (0.49) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL15463889 | 0.81 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL3026759 | 0.81 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL3021914 | 0.81 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL11003021 | 0.80 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL7378393 | 0.79 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL3031020 | 0.79 | ADORA3 (0.82) | KDM4EHSD17B10ALDH1A1CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | claimed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |