Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 15/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 15/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 15/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 15/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 13/20 | 0.57 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.55 |
| ▸ | GABRP | O00591 | 6/20 | 0.55 |
| ▸ | GABRD | O14764 | 6/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.55 |
| ▸ | GABRE | P78334 | 6/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381533 | 0.91 | ALDH1A1 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7384138 | 0.90 | HPGD (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7382595 | 0.90 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7385550 | 0.90 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7382936 | 0.90 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7384757 | 0.90 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7381402 | 0.89 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7383581 | 0.89 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7380859 | 0.87 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7377399 | 0.86 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010077-A | Tranquilizers | A/S FERROSAN (DK) | 1991-04-23 | — | — | US | disclosed |
| EP-0030254-B1 | BETA-CARBOLIN-3-CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR THERAPEUTICAL USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-10-31 | — | — | EP | disclosed |
| US-4371536-A | TRANQUILIZERS | A/S FERROSAN (DK) | 1983-02-01 | — | — | US | disclosed |
| EP-0030254-A1 | Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-06-17 | — | — | EP | disclosed |