Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.51 |
| ▸ | PDE2A | O00408 | 2/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409893 | 0.83 | PDE3B (0.49) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL7382168 | 0.80 | PDE3B (0.45) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL10667819 | 0.80 | PDE3B (0.46) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7381030 | 0.79 | PDE3B (0.43) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL10627611 | 0.79 | PDE3B (0.43) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL7293060 | 0.77 | PDE3B (0.54) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL17185938 | 0.76 | PDE3B (0.53) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL7425735 | 0.76 | PDE3B (0.52) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL11006142 | 0.75 | PDE3B (0.52) | CYP11B2PDE3BPDE3APDE2APDE1A | |
| SCHEMBL7404429 | 0.74 | PDE3B (0.47) | CYP11B2PDE3BPDE3APDE2APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4661496-A | Cardiotonic and antihypertensive 2,4-dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1987-04-28 | — | — | US | disclosed |
| US-4550119-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1985-10-29 | — | — | US | disclosed |
| US-4526982-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY, A CORP. OF DEL. | 1985-07-02 | — | — | US | disclosed |