Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.52 |
| ▸ | PDE2A | O00408 | 2/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17185938 | 0.82 | PDE3B (0.53) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11073696 | 0.82 | PDE3B (0.50) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL16111137 | 0.81 | HTR2C (0.43) | PDE3BPDE3APDE2APDK2CPB2 | |
| SCHEMBL7293060 | 0.80 | PDE3B (0.54) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL11006142 | 0.77 | PDE3B (0.52) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL17868200 | 0.76 | PDK2 (0.41) | PDE3BPDE3APDE2APDK2CPB2 | |
| SCHEMBL10095080 | 0.76 | PDK2 (0.41) | PDE3BPDE3APDE2APDK2CPB2 | |
| SCHEMBL944218 | 0.76 | FGFR1 (0.45) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7381531 | 0.76 | CYP11B2 (0.52) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL16135324 | 0.75 | DRD4 (0.47) | PDK2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200991-B1 | M3-MUSCARINIC OR 5-HT SEROTONINERGIC RECEPTOR ANTAGONISTS; IRRITABLE BOWEL SYNDROME, INCONTINENCE, COGNITION ACTIVATORS; RESPIRATORY SYSTEM DISORDERS | SANOFI-SYNTHELABO (FR) | 2001-03-13 | — | — | US | disclosed |
| EP-1032569-A1 | IMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-SYNTHELABO (FR) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999031097-A1 | IMIDAZOL DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS | SANOFI-SYNTHELABO (FR) | 1999-06-24 | — | — | WO | disclosed |
| WO-1999025710-A1 | IMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-SYNTHELABO (FR) | 1999-05-27 | — | — | WO | disclosed |