SCHEMBL738157

SCHEMBL738157

OCc1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1F

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.31
PYGL P06737 2/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1860377 0.90 PDK2 (0.32) PDK2PYGLCA1CA2
SCHEMBL30021504 0.89
SCHEMBL738705 0.89
SCHEMBL29773568 0.88 CA1 (0.32) PDK2PYGLCA1CA2
SCHEMBL3121365 0.88 CA1 (0.32) PDK2PYGLCA1CA2
SCHEMBL738385 0.84 NOTUM (0.36) PYGLCA1CA2
SCHEMBL1858126 0.84 SSTR5 (0.39) PDK2PYGLCA1CA2
SCHEMBL1610490 0.84 NISCH (0.37) CA1CA2
SCHEMBL2022748 0.83 RECQL (0.30)
SCHEMBL2024236 0.83 RECQL (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12497392-B2 EP300/CBP inhibitor HINOVA PHARMACEUTICALS INC. (CN) 2025-12-16 US disclosed
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2023-11-09 US disclosed
US-20230027088-A1 EP300/CBP INHIBITOR HINOVA PHARMACEUTICALS INC. (CN) 2023-01-26 US disclosed
EP-4043458-A1 EP300/CBP INHIBITOR Hinova Pharmaceuticals Inc. (CN) 2022-08-17 EP disclosed
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-12-29 US disclosed
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2020-05-21 US disclosed
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-03-24 US disclosed
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-11-08 US disclosed
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-03-09 US disclosed
EP-1731512-B9 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT NISSAN CHEMICAL IND LTD (JP) 2017-03-01 EP disclosed
EP-1137641-B1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL CO (JP) 2004-11-10 EP disclosed
US-6500951-B1 RING CLOSING A CARBOXYLIC ACID DERIVATIVE IN PRESENCE OF A NITROGEN CONTAINING AROMATIC COMPOUND AND A BORON COMPOUND; HIGH YIELD AND PURITY SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-12-31 US disclosed
EP-0675118-B1 Biphenylderivatives, process for their preparation and their use as medicaments EISAI CO LTD (JP) 2002-10-09 EP disclosed
US-20020111273-A1 Dihydrobenzene pesticides SZCZEPANSKI HENRY (CH) 2002-08-15 US disclosed
EP-0907634-B1 PESTICIDES BAYER AG (DE) 2002-01-30 EP disclosed
US-6316389-B1 PEST CONTROL, IN PARTICULAR AS FUNGICIDES, ACARICIDES AND INSECTICIDES IN CROP PROTECTION. BAYER AKTIENGESELLSCHAFT (DE) 2001-11-13 US disclosed
EP-1137641-A1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2001-10-04 EP disclosed
US-6281214-B1 USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS EISAI CO., LTD (JP) 2001-08-28 US disclosed
WO-2000034249-A1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-06-15 WO disclosed
EP-0675118-A2 Biphenylderivatives, process for their preparation and their use as medicaments Eisai Co., Ltd. (JP) 1995-10-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12497392-B2 EP300/CBP inhibitor EP300, MLLT1, CREBBP PDK2 2582/4885PYGL 3953/4885CA1 2938/4885
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE HDAC7, ACHE, BRDT PDK2 445/4885PYGL 4070/4885CA1 1596/4885
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide CHRM3, C3AR1, C9 PDK2 2531/4885PYGL 3991/4885CA1 702/4885
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CHRM3, C3AR1, C9 PDK2 2531/4885PYGL 3991/4885CA1 702/4885
US-20230027088-A1 EP300/CBP INHIBITOR EP300, MLLT1, CREBBP PDK2 2582/4885PYGL 3953/4885CA1 2938/4885
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide C3AR1, C5, C9 PDK2 2723/4885PYGL 3936/4885CA1 916/4885
US-20020111273-A1 Dihydrobenzene pesticides CYP8B1, CBR1, DHCR24 PDK2 4461/4885PYGL 4690/4885CA1 629/4885
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 PDK2 2784/4885PYGL 4080/4885CA1 883/4885
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 PDK2 2723/4885PYGL 3936/4885CA1 916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.