Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | RPA1 | P27694 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612165 | 0.89 | GABRP (0.35) | NISCHBACE1APPKDM4EMAPT | |
| SCHEMBL1611478 | 0.88 | CA1 (0.32) | RECQLKDM4EMAPTPKMCA1 | |
| SCHEMBL112195 | 0.88 | CA1 (0.32) | RECQLPKMCA1CA2 | |
| SCHEMBL536510 | 0.88 | PDE3B (0.36) | RECQLKDM4EMAPTPKMCA1 | |
| SCHEMBL1864604 | 0.88 | RECQL (0.34) | RECQLKDM4EMAPTPKMPTGS1 | |
| SCHEMBL1609340 | 0.88 | CYP3A4 (0.36) | RECQLKDM4EMAPTPKMCA1 | |
| SCHEMBL1547527 | 0.88 | PDE3B (0.38) | RECQLKDM4EMAPTPKMCA1 | |
| SCHEMBL1611209 | 0.87 | HTT (0.41) | RECQLKDM4EMAPTPKM | |
| SCHEMBL16274185 | 0.87 | RECQL (0.43) | RECQLKDM4EMAPTPKM | |
| SCHEMBL739909 | 0.87 | KDM4E (0.37) | NISCHRECQLKDM4EMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709983-B1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-04-18 | — | — | EP | disclosed |
| EP-2709983-B1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-04-18 | — | — | EP | disclosed |
| US-8895587-B2 | Insecticidal compounds based on arylthioacetamide derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-8895587-B2 | Insecticidal compounds based on arylthioacetamide derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-8895587-B2 | Insecticidal compounds based on arylthioacetamide derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-17 | — | — | US | disclosed |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-17 | — | — | US | disclosed |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-17 | — | — | US | disclosed |
| EP-2709983-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | Syngenta Participations AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| EP-2069338-B1 | INSECTICIDAL ISOXAZOLINES | BAYER CROPSCIENCE AG (DE) | 2012-11-28 | — | — | EP | disclosed |
| WO-2012156400-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-11-22 | — | — | WO | disclosed |
| WO-2012156400-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-11-22 | — | — | WO | disclosed |
| EP-2332937-A1 | Insecticidal isoxazolines | Bayer CropScience AG (DE) | 2011-06-15 | — | — | EP | disclosed |
| EP-2330106-A1 | Insecticidal isoxazolines | Bayer CropScience AG (DE) | 2011-06-08 | — | — | EP | disclosed |
| US-20110086886-A2 | INSECTICIDAL ISOXAZOLINES | BAYER CROPSCIENCE AG (DE) | 2011-04-14 | — | — | US | disclosed |
| US-20100249191-A1 | N-Methyl benzamide derivatives | BAYER CROPSCIENCE SA (FR) | 2010-09-30 | — | — | US | disclosed |
| EP-2069338-A1 | INSECTICIDAL ISOXAZOLINES | Bayer CropScience AG (DE) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008019760-A1 | INSECTICIDAL ISOXAZOLINES | BAYER CROPSCIENCE AG (DE) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086886-A2 | INSECTICIDAL ISOXAZOLINES | HAX1, INA, CYCS | NISCH 75/4885BACE1 2820/4885APP 3187/4885 |
| US-20100249191-A1 | N-Methyl benzamide derivatives | GNMT, SCN1A, INA | NISCH 80/4885BACE1 4066/4885APP 4507/4885 |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | NAT1, ACHE, CHRM1 | NISCH 23/4885BACE1 2648/4885APP 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.