Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737501 | 0.86 | SIGMAR1 (0.45) | ALDH1A1SIGMAR1OPRM1GAAMAPT | |
| SCHEMBL737490 | 0.86 | SIGMAR1 (0.58) | ALDH1A1SIGMAR1OPRM1MAPTTP53 | |
| SCHEMBL738272 | 0.82 | SIGMAR1 (0.44) | ALDH1A1SIGMAR1OPRM1MAPTLMNA | |
| SCHEMBL735778 | 0.81 | HRH3 (0.49) | ALDH1A1SIGMAR1OPRM1GAAMAPT | |
| SCHEMBL737605 | 0.81 | SIGMAR1 (0.46) | ALDH1A1SIGMAR1OPRM1GAAMAPT | |
| SCHEMBL736984 | 0.79 | SIGMAR1 (0.55) | SIGMAR1OPRM1MAPTLMNAMEN1 | |
| SCHEMBL737212 | 0.79 | SIGMAR1 (0.39) | ALDH1A1SIGMAR1OPRM1GAAMAPT | |
| SCHEMBL739199 | 0.79 | SIGMAR1 (0.50) | ALDH1A1SIGMAR1MAPTLMNAMEN1 | |
| SCHEMBL735769 | 0.76 | HTR1A (0.46) | ALDH1A1SIGMAR1GAALMNAHTR1A | |
| SCHEMBL736347 | 0.75 | SIGMAR1 (0.45) | ALDH1A1SIGMAR1OPRM1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | ALDH1A1 1242/4885SIGMAR1 11/4885OPRM1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.