Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | MGLL | Q99685 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | SCD | O00767 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | FPR2 | P25090 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789239 | 0.89 | MEN1 (0.60) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL3786672 | 0.89 | MGLL (0.60) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL23612093 | 0.87 | MEN1 (0.65) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL12583048 | 0.87 | NPC1 (0.62) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL8322377 | 0.86 | MAPT (0.58) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL3040887 | 0.85 | MGLL (0.59) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL29954612 | 0.85 | MGLL (0.56) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL14183670 | 0.85 | POLB (0.67) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL4201825 | 0.84 | MGLL (0.58) | MAPTHTTALDH1A1MEN1LMNA | |
| SCHEMBL8328458 | 0.84 | MEN1 (0.64) | MAPTHTTALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335753-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335753-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| EP-1015438-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-11-08 | — | — | EP | disclosed |
| EP-1015438-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999011637-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |