Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.55 |
| ▸ | KIT | P10721 | 5/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384334 | 0.83 | PDE3B (0.64) | PDE3BPDE3ARAB9APOLBHPGD | |
| SCHEMBL7382710 | 0.83 | PDE3B (0.55) | PDE3BPDE3ARAB9ACYP1A2CYP2C19 | |
| SCHEMBL7383915 | 0.79 | PDE3B (0.58) | PDE3BPDE3ARAB9APOLBMEN1 | |
| SCHEMBL7383419 | 0.77 | PDE3B (0.70) | PDE3BPDE3A | |
| SCHEMBL7386282 | 0.76 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL16938841 | 0.75 | ALDH1A1 (0.60) | RAB9ACYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL7378034 | 0.74 | PDE3B (0.55) | PDE3BPDE3AKITKDRHPGD | |
| SCHEMBL7382885 | 0.73 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7377905 | 0.73 | PDE3B (0.64) | PDE3BPDE3AKITKDRHPGD | |
| SCHEMBL7377041 | 0.73 | PDE3B (0.76) | PDE3BPDE3AKDRJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | claimed |
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | disclosed |