Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.77 |
| ▸ | DRD4 | P21917 | 3/20 | 0.77 |
| ▸ | DRD3 | P35462 | 3/20 | 0.77 |
| ▸ | HTR1A | P08908 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559091 | 0.91 | DRD2 (0.84) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL11388217 | 0.87 | DRD2 (1.00) | DRD2DRD4DRD3HTR1A | |
| Hydrochloric Acid SCHEMBL9359305 | 0.86 | DRD2 (0.97) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL31208114 | 0.86 | DRD2 (0.75) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL31208115 | 0.86 | DRD2 (0.75) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL31208122 | 0.86 | DRD2 (0.75) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL7378729 | 0.86 | DRD2 (0.74) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL7389987 | 0.84 | DRD2 (0.75) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL9558117 | 0.83 | DRD2 (0.70) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL9757624 | 0.82 | DRD2 (0.76) | DRD2DRD4DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430056-A | Treatment of disorders of central nervous, cardiovascular and endocrine systems | DISCOVERY THERAPEUTICS, INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5358971-A | For disorders of CNS, cardiovascular and endocrine systems, inducing anorexia and weight loss | WHITBY RESEARCH, INC. (US) | 1994-10-25 | — | — | US | disclosed |
| US-5274003-A | A 3-naphthyloxy- or -thioaklyleneamino-8-hydroxytetralin derivative | WHITBY RESEARCH, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0463119-A4 | SUBSTITUTED 2-AMINOTETRALINS | — | 1992-01-22 | — | — | EP | disclosed |
| EP-0463119-A1 | use of SUBSTITUTED 2-AMINOTETRALINS for the preparation of a medicament for inducing anorexia or weight loss. | Whitby Research Incorporated (US) | 1992-01-02 | — | — | EP | disclosed |
| WO-1991000727-A1 | SUBSTITUTED 2-AMINOTETRALINS | WHITBY RESEARCH, INC. (US) | 1991-01-24 | — | — | WO | disclosed |